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The Micronization of Drug Particles by the Rapid Expansion of a Supercritical Solution @mictotech(India)Ankleshwar
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Introduction
A common problem in the pharmaceutical industry is that many drugs demonstrate poor solubility in water. Drugs that exhibit slow dissolution rates are less effective because they cannot quickly absorb into the gastrointestinal tract.

Typically, the pharmaceutical industry uses micronization techniques to increase the dissolution rates of drugs into biological fluids. Particle size reduction methods include recrystallization of the solute particles from solutions using liquid antisolvents, along with labor intensive techniques like crushing, milling, grinding, freeze drying, and spray-drying. Problems with traditional methods include the use of large amounts of solvent, solvent residues, broad particle size distributions, as well as thermal and chemical degradation of products.

The rapid expansion of supercritical solutions (RESS) is an alternative technique for the micronization of particles using supercritical CO2 to quickly and naturally reduce the particle sizes of various drugs. Micronization by RESS involves dissolving a drug compound in a supercritical fluid, and then reducing the pressure across an expansion devise. The rapid depressurization of the supercritical phase causes decreased solubility of the solute, and precipitation of the solute as a powder in a gas phase. The result of the process is the formation of fine particles with a narrow size distribution without the use of solvents or surfactants.
one step solution for micronization is Microtechindia Ankleshwar , haresh Patel